(S,S,S)-AHPC hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

(S,S,S)-AHPC 盐酸盐是一种 VHL 氨基结构单元，是用作 (S,R,S)-AHPC 阴性对照的配体。

(S,S,S)-AHPC hydrochloride is a VHL amino building block, is a ligand used as a negative control for (S,R,S)-AHPC. It is the VH032-based VHL ligand used in the recruitment of the VHL protein.

The VHL protein is a substrate recognition subunit of two ubiquitously expressed and biologically important Cullin RING E3 ubiquitin ligase complexes. VHL is one of the most popular E3 ligases being recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a target protein.

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(S,S,S)-VH032-NH2 hydrochloride

PROTACs

E3 Ligase Ligand

VHL

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2115897-23-7

467.02

C22H31ClN4O3S

>98% (HPLC)

H2O: 99 mg/mL (211.98 mM; Need ultrasonic); DMSO: 60 mg/mL (128.47 mM; Need ultrasonic)

O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)N)=O)C[C@@H](O)C3.[H]Cl

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(-20℃)

With Ice Pack

≥ 2 years